Property Summary

NCBI Gene PubMed Count 8
PubMed Score 4.19
PubTator Score 5.13

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
osteosarcoma 7933 2.36248558180646E-7
group 4 medulloblastoma 1875 4.81003022943902E-4
glioblastoma 5572 8.16438708109222E-4
ovarian cancer 8492 8.79014972020025E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00271559338826369
adult high grade glioma 2148 0.0086825769009121
progressive supranuclear palsy 674 0.0182832600303962
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0

Expression

  Differential Expression (7)

Disease log2 FC p
osteosarcoma -2.378 0.000
group 4 medulloblastoma 1.400 0.000
glioblastoma -1.300 0.001
intraductal papillary-mucinous adenoma (... 1.100 0.003
adult high grade glioma -1.100 0.009
progressive supranuclear palsy -1.200 0.018
ovarian cancer -1.100 0.001

Synonym

Accession Q06730 A8K9X9 B4E0M8 F6TH33 F8WAJ5 P17013 Q5VZ86
Symbols KOX2
KOX5
KOX31
NF11A
ZNF11
ZNF33
ZZAPK
ZNF11A

Gene

PANTHER Protein Class (1)

  Ortholog (1)

Species Source
Macaque OMA Inparanoid

Gene RIF (1)

PMID Text
12535642 Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression.

AA Sequence

MNKVEQKSQESVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCVHKPEVIFRLQQGEEP      1 - 70
WKQEEEFPSQSFPVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGDVIGIPFNVDVSSFPSRKMFCQ     71 - 140
CDSCGMSFNTVSELVISKINYLGKKSDEFNACGKLLLNIKHDETHTQEKNEVLKNRNTLSHHEETLQHEK    141 - 210
IQTLEHNFEYSICQETLLEKAVFNTQKRENAEENNCDYNEFGRTLCDSSSLLFHQISPSRDNHYEFSDCE    211 - 280
KFLCVKSTLSKPHGVSMKHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQRVH    281 - 350
TGQKPFQCNECEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGKT    351 - 420
FCQKSDLTKHQRTHTGLKPYECYECGKSFRVTSHLKVHQRTHTGEKPFECLECGKSFSEKSNLTQHQRIH    421 - 490
IGDKSYECNACGKTFYHKSLLTRHQIIHTGWKPYECYECGKTFCLKSDLTVHQRTHTGQKPFACPECGKF    491 - 560
FSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIH    561 - 630
IGEKPYKCNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLIFHERKHTGEKPYECNECGKF    631 - 700
FRHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSELAQHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRRH    701 - 770
IGENLMNEMDIRNFQPQVSLHNASEYSHCGESPDDILNVQ                                  771 - 810
//

Text Mined References (11)

PMID Year Title
25755297 2015 System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
25218447 2014 Uncovering global SUMOylation signaling networks in a site-specific manner.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12766061 2003 Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.
12535642 2003 A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8464732 1993 Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.
7584044 1994 Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.
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