Tbio GABPA GA-binding protein alpha chain

Protein Summary

Description

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q06546
• Q12939
• GABP subunit alpha

Gene Name

• GABPA

Ensembl ID

• ENST00000354828
• ENSP00000346886
• ENSG00000154727
• ENST00000400075
• ENSP00000382948

Symbol

• E4TF1A
• NFT2
• NRF2
• NRF2A
• E4TF1A
• E4TF1-60
• RCH04A07

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
protein domain	0.92
histone modification site profile	0.87
transcription factor binding site profile	0.87
biological process	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ga-binding Protein Alpha Chain

Protein / Signaling Molecule / Ga-binding Protein Alpha Chain

Protein / Nucleic Acid Binding / Ga-binding Protein Alpha Chain

Protein / ... / Winged Helix/forkhead Transcription Factor / Ga-binding Protein Alpha Chain

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Ga-binding Protein Alpha Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.91   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 380   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.91   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0