Tchem RBPJ Recombining binding protein suppressor of hairless

Protein Summary

Description

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• Q06330
• B4DY22
• Q5XKH9
• Q6P1N3

Gene Name

• RBPJ

Ensembl ID

• ENST00000342295
• ENSP00000345206
• ENSG00000168214
• ENST00000342320
• ENSP00000340124
• ENST00000345843
• ENSP00000305815
• ENST00000348160
• ENSP00000339699
• ENST00000355476
• ENSP00000347659
• ENST00000361572
• ENSP00000354528
• ENST00000507561
• ENSP00000423907

Symbol

• IGKJRB
• IGKJRB1
• RBPJK
• RBPSUH
• SUH
• csl
• AOS3
• CBF1
• KBF2
• RBP-J
• RBPJK
• IGKJRB
• RBPSUH
• IGKJRB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	1
molecular function	0.97
transcription factor binding site profile	0.96
transcription factor	0.93

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Recombining Binding Protein Suppressor Of Hairless

Protein / Nucleic Acid Binding / Recombining Binding Protein Suppressor Of Hairless

DTO Classes

Protein / Nucleic Acid Binding / Recombining Binding Protein Suppressor Of Hairless

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.17   (req: < 5)

Gene RIFs: 110   (req: <= 3)

Antibodies: 332   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.17   (req: >= 5)

Gene RIFs: 110   (req: > 3)

Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0