Tclin PPAT Amidophosphoribosyltransferase

Protein Summary

Description

The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q06203
• ATase

Gene Name

• PPAT

Ensembl ID

• ENST00000264220
• ENSP00000264220
• ENSG00000128059

Symbol

• GPAT
• GPAT
• PRAT
• ATASE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
transcription factor perturbation	0.88
protein domain	0.85
histone modification site profile	0.78
microRNA	0.65

Protein Classes

PANTHER Classes

Protein / Transferase / Amidophosphoribosyltransferase

Protein / ... / Cysteine Protease / Amidophosphoribosyltransferase

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Amidophosphoribosyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.72   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 298   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.72   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1