Tbio KDSR 3-ketodihydrosphingosine reductase

Protein Summary

Description

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q06136
• B2R5Y1
• B4DMX0
• KDS reductase

Gene Name

• KDSR

Ensembl ID

• ENST00000326575
• ENSP00000312939
• ENSG00000119537
• ENST00000406396
• ENSP00000385083
• ENST00000645214
• ENSP00000494352

Symbol

• FVT1
• SDR35C1
• DHSR
• FVT1
• EKVP4
• SDR35C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
histone modification site profile	0.91
kinase perturbation	0.88
transcription factor perturbation	0.88
microRNA	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.37   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.37   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0