MBTD1
MBT domain-containing protein 1
Protein Summary
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4.
- ENST00000376381
- ENSP00000365561
- ENSG00000011258
- ENST00000405860
- ENSP00000386072
- ENST00000415868
- ENSP00000403946
- ENST00000586178
- ENSP00000468304
- SA49P01
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.87 | ||
transcription factor perturbation | 0.84 | ||
virus perturbation | 0.79 | ||
transcription factor binding site profile | 0.75 | ||
small molecule perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.9 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 99 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.9 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 99 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0