SLC18A2
Synaptic vesicular amine transporter
Protein Summary
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473). Requisite for vesicular amine storage prior to secretion via exocytosis. This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]
- ENST00000298472
- ENSP00000298472
- ENSG00000165646
- ENST00000644641
- ENSP00000496339
- SVMT
- VMAT2
- SVAT
- SVMT
- VAT2
- VMAT2
- PKDYS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.89 | ||
biological process | 0.85 | ||
kinase perturbation | 0.81 | ||
molecular function | 0.79 | ||
chemical | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1585.04 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 358 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1585.04 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 358 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 10