Tchem FPGS Folylpolyglutamate synthase, mitochondrial

Protein Summary

Description

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q05932
• B3KPW4
• B7Z2Z3
• F5H0K6
• Q5JU19
• Q5JU22
• Q6P2P6

Gene Name

• FPGS

Ensembl ID

• ENST00000373225
• ENSP00000362322
• ENSG00000136877
• ENST00000373247
• ENSP00000362344
• ENST00000393706
• ENSP00000377309

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
molecular function	0.86
transcription factor binding site profile	0.79
protein domain	0.73
transcription factor	0.72

Protein Classes

PANTHER Classes

Protein / Ligase / Folylpolyglutamate Synthase, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Folylpolyglutamate Synthase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.49   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.49   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0