| Tbio | Homeobox protein engrailed-1 |
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Adenoid Cystic | 99 | 0.0 | 0.0 |
| Neoplasm Invasiveness | 161 | 0.0 | 0.0 |
| Nervous System Diseases | 53 | 0.0 | 0.0 |
| Salivary Gland Neoplasms | 46 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Adenoid Cystic Carcinoma | 99 |
| Schizophrenia | 1160 |
| nervous system disorder | 53 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.4e-09 |
| glioblastoma | 5792 | 1.2e-03 |
| Breast cancer | 3578 | 1.5e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.3e-02 |
| adult high grade glioma | 3801 | 1.7e-02 |
| medulloblastoma, large-cell | 6241 | 1.9e-02 |
| primitive neuroectodermal tumor | 3035 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 540 | 0.0 | 0.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Parkinson's disease | 392 | 3.916 | 2.0 |
| Smith-Magenis syndrome | 29 | 3.079 | 1.5 |
| Lesch-Nyhan syndrome | 12 | 3.071 | 1.5 |
| Syndactyly | 88 | 3.069 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.900 | 1.7e-02 |
| Breast cancer | 1.600 | 1.5e-03 |
| glioblastoma | 1.900 | 1.2e-03 |
| medulloblastoma, large-cell | 1.200 | 1.9e-02 |
| primitive neuroectodermal tumor | 1.400 | 4.5e-02 |
| psoriasis | -1.800 | 8.4e-09 |
| subependymal giant cell astrocytoma | 2.465 | 1.3e-02 |
| Accession | Q05925 Q4ZG44 Homeobox protein en-1 |
| Symbols |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPPAAPCLPPLAH 1 - 70 HPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGG 71 - 140 RVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAVA 141 - 210 AAAAAAAAKPSDTGGGGSGGGAGSPGAQGTKYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTR 211 - 280 YSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIW 281 - 350 FQNKRAKIKKATGIKNGLALHLMAQGLYNHSTTTVQDKDESE 351 - 392 //
