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Tclin
PTK2
Focal adhesion kinase 1

Protein Summary
Description
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340930
  • ENSP00000341189
  • ENSG00000169398
  • ENST00000395218
  • ENSP00000378644
  • ENST00000521059
  • ENSP00000429474
  • ENST00000522684
  • ENSP00000429911

Symbol
  • FAK
  • FAK1
  • FAK
  • FADK
  • FAK1
  • FRNK
  • PPP1R71
  • p125FAK
  • pp125FAK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
kinase
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1491.49   (req: < 5)
Gene RIFs: 773   (req: <= 3)
Antibodies: 2638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1491.49   (req: >= 5)
Gene RIFs: 773   (req: > 3)
Antibodies: 2638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 459
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1