Tchem MST1R Macrophage-stimulating protein receptor

Protein Summary

Description

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q04912
• A0A087WZG2
• B5A944
• B5A945
• B5A946
• B5A947
• MSP receptor

Gene Name

• MST1R

Ensembl ID

• ENST00000296474
• ENSP00000296474
• ENSG00000164078
• ENST00000344206
• ENSP00000341325
• ENST00000621387
• ENSP00000482642

Symbol

• PTK8
• RON
• RON
• PTK8
• CD136
• NPCA3
• CDw136

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
hub protein	0.96
biological process	0.75
PubMedID	0.7

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Met Family / Macrophage-stimulating Protein Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.93   (req: < 5)

Gene RIFs: 138   (req: <= 3)

Antibodies: 831   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.93   (req: >= 5)

Gene RIFs: 138   (req: > 3)

Antibodies: 831   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1