Tbio CD164 Sialomucin core protein 24

Protein Summary

Description

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q04900
• B4DQ85
• E1P5E7
• E1P5E8
• E1P5E9
• O95413
• Q5JSU6
• Q9BPV0
• Q9NR26
• MUC-24

Gene Name

• CD164

Ensembl ID

• ENST00000275080
• ENSP00000275080
• ENSG00000135535
• ENST00000310786
• ENSP00000309376
• ENST00000324953
• ENSP00000314177
• ENST00000413644
• ENSP00000402237
• ENST00000512821
• ENSP00000427546

Symbol

• DFNA66
• MGC-24
• MUC-24
• MGC-24v
• endolyn

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
virus perturbation	0.98
transcription factor perturbation	0.91
kinase perturbation	0.84
microRNA	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.19   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.19   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0