Property Summary

NCBI Gene PubMed Count 31
PubMed Score 32.49
PubTator Score 29.32

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Spontaneous abortion 108
Disease Target Count P-value
juvenile dermatomyositis 1189 6.14568990433707E-11
lung adenocarcinoma 2714 8.78865299308102E-9
osteosarcoma 7933 1.22002605960738E-7
ovarian cancer 8492 1.06591144994276E-5
Breast cancer 3099 1.27060817611689E-5
glioblastoma 5572 4.38042784331934E-5
atypical teratoid / rhabdoid tumor 4369 6.52336943488564E-5
pediatric high grade glioma 2712 8.49227492215191E-5
Down syndrome 548 2.06754500229234E-4
acute quadriplegic myopathy 1157 5.94858258644561E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 6.58011621913403E-4
dermatomyositis 967 8.19437437160496E-4
Multiple myeloma 1328 0.00109667382571441
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00177438120750314
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00282653900686018
pilocytic astrocytoma 3086 0.00321465480389238
medulloblastoma 1524 0.00890985661084232
hereditary spastic paraplegia 313 0.0102814573179101
progressive supranuclear palsy 674 0.0259636957610584
ependymoma 2514 0.0447569651203056
aldosterone-producing adenoma 664 0.0458139891813478
Disease Target Count Z-score Confidence
Nonsyndromic deafness 121 0.0 4.0
Disease Target Count Z-score Confidence
Pollen allergy 6 3.855 1.9
Bruton-type agammaglobulinemia 2 3.3 1.7



Accession Q04900 B4DQ85 E1P5E7 E1P5E8 E1P5E9 O95413 Q5JSU6 Q9BPV0 Q9NR26 MUC-24
Symbols DFNA66


PANTHER Protein Class (1)

  Ortholog (9)

 CSPA Cell Line (4)

Gene RIF (14)

26197441 This paper identified a new Deafness, Autosomal Dominant locus located on chromosome 6q15-21 and implicated CD164 as a novel gene for hearing impairment.
25980612 Infectious wild type HIV-1 production is restricted by 293T cells over-expressing CD164
25275127 Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD164
24756834 miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164.
24094005 Increased expression of CD164 is involved in ovarian cancer progression via the SDF-1alpha/CXCR4 axis.
22409183 CD164 is highly expressed in the colon cancer sites, and it promotes HCT116 colon cancer cell proliferation and metastasis both in vitro and in vivo
21999799 C-jun and HIF-1alpha bound to the CD164 promoter region and activated the CD164 expression.
20872290 Conclude that assessment of allergen-induced basophil CD164 upregulation is a very useful method for in vitro determination of allergy to grass pollens.
18854154 Infectious wild type HIV-1 production is restricted by 293T cells over-expressing CD164
17077324 sialomucin endolyn (CD164), an adhesion receptor that regulates the adhesion of CD34+ cells to bone marrow stroma and the recruitment of CD34+CD38(lo/-) cells into cycle, associates with CXCR4

AA Sequence


Text Mined References (33)

PMID Year Title
27517145 2016 CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling.
27376157 2016 MicroRNA-124 suppresses tumor cell proliferation and invasion by targeting CD164 signaling pathway in non-small cell lung cancer.
26524186 2016 Expression of CD164 on Malignant T cells in Sézary Syndrome.
26197441 2015 A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment.
25416956 2014 A proteome-scale map of the human interactome network.
24756834 2014 miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164.
24094005 2013 CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1?/CXCR4 axis.
23792457 2014 CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients.
23446634 2013 Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
22409183 2012 Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo.