CHRNE
Acetylcholine receptor subunit epsilon
Protein Summary
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome. [provided by RefSeq, Sep 2009]
- ENST00000293780
- ENSP00000293780
- ENSG00000108556
- ENST00000649488
- ENSP00000497829
- ACHRE
- ACHRE
- CMS1D
- CMS1E
- CMS2A
- CMS4A
- CMS4B
- CMS4C
- FCCMS
- SCCMS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
molecular function | 0.84 | ||
disease perturbation | 0.74 | ||
gene perturbation | 0.74 | ||
phenotype | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.94 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.94 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4