| Tbio | Centromere protein C |
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 37 |
| Grant Count | 25 |
| R01 Count | 17 |
| Funding | $2,716,201.77 |
| PubMed Score | 115.33 |
| PubTator Score | 96.24 |
| Disease | Z-score | Confidence |
|---|---|---|
| Systemic scleroderma 66 | 4.171 | 2.1 |
| CREST syndrome 10 | 4.037 | 2.0 |
| Primary biliary cirrhosis 43 | 3.326 | 1.7 |
| Dyskinesia of esophagus 3 | 3.074 | 1.5 |
| acute myeloid leukemia 780 |
| PMID | Text |
|---|---|
| 26878239 | A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3. |
| 26527398 | CENP-C and CENP-I are key factors connecting kinetochore to CENP-A assembly. |
| 26124289 | CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. |
| 25997930 | HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. |
| 25954010 | CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity. |
| 25942623 | CENP-B directly binds both CENP-A's amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly |
| 25843710 | We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and CENP-T, two key components that are necessary for the formation of functional kinetochores |
| 25660545 | CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation. |
| 25408271 | The CENP-A/histone H3.3 nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing tumor cells. |
| 22540025 | CENP-C works as an important factor for centromeric M18BP1 recruitment |
| More... |
MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTC 1 - 70 IQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRN 71 - 140 INDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFD 141 - 210 DKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIV 211 - 280 RHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKH 281 - 350 HNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK 351 - 420 QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRK 421 - 490 DKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKS 491 - 560 TKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEADLAKKKN 561 - 630 LDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKND 631 - 700 VDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISG 701 - 770 VLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL 771 - 840 VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYIL 841 - 910 STGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR 911 - 943 //
| PMID | Year | Title |
|---|---|---|
| 27499292 | 2016 | The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity. |
| 26878239 | 2016 | CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres. |
| 26527398 | 2015 | CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly. |
| 26124289 | 2015 | CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores. |
| 25997930 | 2015 | The human papillomavirus18 E7 protein inhibits CENP-C binding to ?-satellite DNA. |
| 25954010 | 2015 | Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. |
| 25942623 | 2015 | DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. |
| 25843710 | 2015 | HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment. |
| 25755297 | 2015 | System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. |
| 25660545 | 2015 | Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T. |
| More... |
