Tchem PPARD Peroxisome proliferator-activated receptor delta

Protein Summary

Description

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• Q03181
• A8K6J6
• B4E3V3
• B6ZGS1
• B7Z3W1
• E9PE18
• Q5D1P0
• Q7Z5K0
• Q9BUD4
• PPAR-delta

Gene Name

• PPARD

Ensembl ID

• ENST00000311565
• ENSP00000310928
• ENSG00000112033
• ENST00000337400
• ENSP00000337063
• ENST00000360694
• ENSP00000353916
• ENST00000418635
• ENSP00000413314
• ENST00000448077
• ENSP00000414372

Symbol

• NR1C2
• PPARB
• FAAR
• NUC1
• NUCI
• NR1C2
• NUCII
• PPARB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.99
biological term	0.98
protein domain	0.92
transcription factor binding site profile	0.91

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Peroxisome Proliferator-activated Receptor Delta

Protein / Receptor / Peroxisome Proliferator-activated Receptor Delta

Protein / Nucleic Acid Binding / Peroxisome Proliferator-activated Receptor Delta

Protein / ... / C4 Zinc Finger Nuclear Receptor / Peroxisome Proliferator-activated Receptor Delta

DTO Classes

Protein / Nuclear Receptor / Peroxisome Proliferator-activated Receptors / Peroxisome Proliferator-activated Receptor Delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.44   (req: < 5)

Gene RIFs: 273   (req: <= 3)

Antibodies: 572   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.44   (req: >= 5)

Gene RIFs: 273   (req: > 3)

Antibodies: 572   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 79

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 675

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1