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Tchem
MLLT1
Protein ENL

Protein Summary
Description
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252674
  • ENSP00000252674
  • ENSG00000130382

Symbol
  • ENL
  • LTG19
  • YEATS1
  • ENL
  • LTG19
  • YEATS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.82
disease perturbation
0.74
tissue sample
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.3   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.3   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0