Tbio Dystonin

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Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.

This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]

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Property Summary

NCBI Gene PubMed Count	77
PubMed Score	505.96

PubTator Score	512.46

Knowledge Summary

Patent

No data available

TINX Plot

Disease (7)

Disease	Target Count	Z-score	Confidence
Epidermolysis bullosa simplex, autosomal recessive	3	0.0	0.0
NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE VI	1	0.0	0.0

Disease	Target Count
Absent reflex	92
Absent tendon reflex	92
Alacrima	9
Apnea	45
Atrophic scar	18
Autosomal recessive predisposition	1442
Blotching pigmentation of the skin	2
Bradycardia	36
Clenched hands	6
Congenital clubfoot	109
Contracture	96
Contracture of joint	93
Corneal Scar	7
Elevated heart rate	25
Feeding difficulties	127
Fever	138
Flexion contracture	93
Flexion contractures of joints	93
Growth delay	114
Growth failure	114
Growth retardation	115
Hyperhidrosis disorder	81
Increased sweating	81
Limited hip extension	4
Neonatal Hypotonia	64
Open mouth	45
Poor growth	114
Reflex, Deep Tendon, Absent	92
Respiratory Insufficiency	132
Respiratory function loss	121
Sensory neuropathy	20
Sweating	81
Tachycardia	43
Very poor growth	114

Disease	Target Count	P-value
non-small cell lung cancer	2890	4.2e-14
ovarian cancer	8520	5.3e-09
psoriasis	6694	1.1e-06
lung adenocarcinoma	2716	1.1e-06
malignant mesothelioma	3232	1.1e-05
tuberculosis and treatment for 3 months	179	3.8e-05
Pick disease	1894	3.8e-05
adult high grade glioma	3801	2.1e-04
glioblastoma	5792	7.0e-04
breast carcinoma	1638	1.5e-03
astrocytic glioma	2597	2.6e-03
progressive supranuclear palsy	676	2.8e-03
lung cancer	4740	2.9e-03
atypical teratoid / rhabdoid tumor	5112	4.0e-03
pituitary cancer	1972	4.1e-03
primary pancreatic ductal adenocarcinoma	1109	4.3e-03
interstitial cystitis	2312	7.6e-03
hereditary spastic paraplegia	318	8.2e-03
ependymoma	4679	9.3e-03
cutaneous lupus erythematosus	1057	1.3e-02
pancreatic cancer	2398	1.7e-02
medulloblastoma	720	1.8e-02
oligodendroglioma	2850	1.8e-02
nasopharyngeal carcinoma	1058	1.8e-02
osteosarcoma	7950	1.8e-02
invasive ductal carcinoma	2951	2.3e-02
acute myeloid leukemia	783	2.6e-02
Breast cancer	3578	2.7e-02
colon cancer	1478	3.3e-02
esophageal adenocarcinoma	737	4.1e-02

Disease	Target Count	Confidence
Carcinoma	11493	1.7
Kidney cancer	2613	1.1
Large intestine cancer	126	1.0
Liver cancer	604	1.0

Disease	Target Count	Z-score	Confidence
Epidermolysis bullosa	21	5.591	2.8
Neurodegenerative disease	414	0.0	4.0
Neuropathy	261	0.0	4.0

Disease	Target Count	Z-score	Confidence
Bullous pemphigoid	18	7.902	4.0
Dermatitis	157	4.736	2.4
Herpes gestationis	6	4.297	2.1
Lichen planus	16	3.539	1.8
Kindler syndrome	11	3.407	1.7
Epidermolysis bullosa simplex with muscular dystrophy	3	3.056	1.5

Disease	Target Count
EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE 2	1
Hereditary sensory and autonomic neuropathy type 6	1

Differential Expression (30)

Disease	log2 FC	p
Breast cancer	-3.700	2.7e-02
ovarian cancer	-3.400	5.3e-09
acute myeloid leukemia	-1.500	2.6e-02
adult high grade glioma	1.100	2.1e-04
astrocytic glioma	1.800	2.6e-03
atypical teratoid / rhabdoid tumor	1.600	4.0e-03
breast carcinoma	-2.000	1.5e-03
colon cancer	-1.800	3.3e-02
cutaneous lupus erythematosus	-1.200	1.3e-02
ependymoma	1.700	9.3e-03
esophageal adenocarcinoma	-2.000	4.1e-02
glioblastoma	1.100	7.0e-04
hereditary spastic paraplegia	-1.240	8.2e-03
interstitial cystitis	-3.000	7.6e-03
invasive ductal carcinoma	-1.100	2.3e-02
lung adenocarcinoma	-1.400	1.1e-06
lung cancer	-1.200	2.9e-03
malignant mesothelioma	-1.100	1.1e-05
medulloblastoma	1.100	1.8e-02
nasopharyngeal carcinoma	1.100	1.8e-02
non-small cell lung cancer	4.523	4.2e-14
oligodendroglioma	1.600	1.8e-02
osteosarcoma	1.950	1.8e-02
pancreatic cancer	1.100	1.7e-02
Pick disease	-1.300	3.8e-05
pituitary cancer	1.400	4.1e-03
primary pancreatic ductal adenocarcinoma	1.267	4.3e-03
progressive supranuclear palsy	-1.700	2.8e-03
psoriasis	-1.100	1.1e-06
tuberculosis and treatment for 3 months	1.200	3.8e-05

Nerve - Tibial 18,007

Colon - Sigmoid 18,089

Uterus 17,618

Vagina 17,834

Artery - Tibial 17,631

Skin - Not Sun Exposed (Suprapubic) 18,081

Brain - Spinal cord (cervical c-1) 17,973

Skin - Sun Exposed (Lower leg) 17,968

Artery - Coronary 17,949

Artery - Aorta 17,896

Lung 18,057

Esophagus - Gastroesophageal Junction 18,000

Esophagus - Muscularis 18,017

Ovary 17,971

Cells - Transformed fibroblasts 17,577

Brain - Cerebellum 17,983

Brain - Substantia nigra 17,981

Stomach 17,879

Breast - Mammary Tissue 18,103

Prostate 18,213

Brain - Cerebellar Hemisphere 18,015

Brain - Nucleus accumbens (basal ganglia... 18,024

Minor Salivary Gland 18,005

Brain - Caudate (basal ganglia) 18,001

Brain - Cortex 18,039

Brain - Amygdala 18,006

Adipose - Subcutaneous 18,110

Brain - Hypothalamus 18,169

Brain - Putamen (basal ganglia) 17,863

Brain - Hippocampus 18,011

Brain - Frontal Cortex (BA9) 18,069

Muscle - Skeletal 17,778

Heart - Atrial Appendage 17,896

Esophagus - Mucosa 18,076

Adipose - Visceral (Omentum) 17,937

Pituitary 18,147

Brain - Anterior cingulate cortex (BA24) 17,989

Colon - Transverse 17,825

Spleen 17,614

Cells - EBV-transformed lymphocytes 18,186

Adrenal Gland 18,071

Thyroid 18,024

Small Intestine - Terminal Ileum 17,954

Testis 18,518

Heart - Left Ventricle 18,006

Liver 18,071

Kidney - Cortex 17,329

Pancreas 18,123

Whole Blood 17,439

Adult Spinal Cord 7,594

Adult Frontal Cortex 9,048

Adult Retina 10,115

Fetal Brain 7,866

Adult Liver 9,113

Adult Pancreas 9,168

Adult Adrenal 8,475

Adult Ovary 10,192

Fetal Ovary 9,118

Fetal Heart 9,228

Adult Esophagus 4,936

Adult Colon 7,915

Adult Rectum 8,022

Adult Kidney 6,723

Adult Testis 10,836

Adult Urinary Bladder 7,592

Adult Heart 6,506

Adult Lung 6,663

Adult Prostate 8,952

Fetal Liver 8,402

Fetal Gut 8,640

Adult Gallbladder 7,612

CD4 Cells 7,773

CD8 Cells 9,840

Monocytes 7,422

B Cells 9,086

Fetal Testis 7,955

NK Cells 8,475

Platelets 6,131

Adrenal gland

Blood platelet

Brain

Colon

Frontal lobe

Gall bladder

Gut

Heart

Kidney

Liver

Lung

B-lymphocyte

Natural killer cell

Esophagus

Ovary

Pancreas

Placenta 6,083

Prostate gland

Rectum

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

Cervical carcinoma cell 4,944

Duodenum 136

Erythroleukemia cell 4,300

Hippocampus 531

Keratinocyte 139

Liver 5,008

Pineal gland 3

Placenta 3,079

Retina 337

Tongue 470

See source...

Bpe 8

Skin 763

Photophore 8

Filament 144

Blood 1,962

See source...

Synonym

Accession	Q03001 B7Z3H1 E7ERU0 O94833 Q12825 Q13266 Q13267 Q13775 Q5TBT0 Q5TBT2 Q5TF23 Q5TF24 Q8N1T8 Q8N8J3 Q8WXK8 Q8WXK9 Q96AK9 Q96DQ5 Q96J76 Q96QT5 Q9H555 Q9UGD7 Q9UGD8 Q9UN10
Symbols	DT BPA DMH BP240 BPAG1 EBSB2 HSAN6 MACF2 CATX15 CATX-15 D6S1101

Gene

DST

PANTHER Protein Class (3)

cytoskeletal protein 441

intermediate filament 15

intermediate filament binding protein 15

Ortholog (1)

Species	Source	Disease
Mouse 16,570	Inparanoid OMA

UniProt Keyword (33)

Complete proteome 20,231

Metal-binding 3,672

Nucleus 5,259

Polymorphism 12,194

Reference proteome 20,231

Repeat 4,916

Alternative splicing 10,528

Cell projection 826

Cytoplasm 4,952

Cytoskeleton 1,182

See all...

GO Function (6)

protein homodimerization activity 801

integrin binding 112

calcium ion binding 690

actin binding 272

protein C-terminus binding 191

microtubule plus-end binding 12

GO Component (23)

nucleus 5,097

cytoplasm 4,094

cytosol 4,834

integral component of membrane 3,665

cytoplasmic vesicle 217

endoplasmic reticulum membrane 879

extracellular exosome 2,767

cell cortex 118

axon 250

microtubule cytoskeleton 134

See all...

GO Process (10)

cell adhesion 458

microtubule cytoskeleton organization 66

integrin-mediated signaling pathway 85

response to wounding 65

cytoskeleton organization 109

cell motility 24

hemidesmosome assembly 12

intermediate filament cytoskeleton organ... 14

maintenance of cell polarity 6

retrograde axonal transport 9

Compartment GO Term (91)

A band 43

Actin cytoskeleton 521

Axon 294

Basal lamina 105

Basal part of cell 27

Basal plasma membrane 19

Basement membrane 181

Basolateral plasma membrane 166

Cell 16,178

Cell cortex 223

Cell junction 960

Cell leading edge 326

Cell part 16,177

Cell periphery 5,382

Cell projection 1,541

See all...

IMPC Phenotype (3)

preweaning lethality, incomplete penetra... 499

abnormal embryo size 220

decreased circulating sodium level 22

OMIM Phenotype (2)

Phenotype: ?Neuropathy, hereditary senso... 1

Epidermolysis bullosa simplex, autosomal... 1

MGI Phenotype (17)

growth-size-body region phenotype 4,157

integument phenotype 1,874

homeostasis-metabolism phenotype 4,747

cellular phenotype 3,637

craniofacial phenotype 1,182

vision-eye phenotype 1,622

digestive-alimentary phenotype 1,398

limbs-digits-tail phenotype 1,071

nervous system phenotype 3,447

hematopoietic system phenotype 3,383

See all...

GWAS Trait (5)

Schizophrenia 533

Cerebrospinal fluid clusterin levels 19

Alzheimer disease and age of onset 124

Menarche (age at onset) 122

Attention function in attention deficit ... 10

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (8)

http://pathwaycommons.org/pc2/Pathway_9c... 74

http://pathwaycommons.org/pc2/Pathway_2d... 54

Extracellular matrix organization 297

Cell junction organization 87

Cell-Cell communication 120

Assembly of collagen fibrils and other m... 57

Collagen formation 89

Type I hemidesmosome assembly 8

PDB (1)

...
More...

Gene RIF (27)

AA Sequence

MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLI      1 - 70
SLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS     71 - 140
DIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA    141 - 210
NLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMV    211 - 280
NYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL    281 - 350
QGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLES    351 - 420
GVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRIL    421 - 490
TTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFP    491 - 560
SGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD    561 - 630
LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDT    631 - 700
LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH    701 - 770
PARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI    771 - 840
HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDE    841 - 910
CVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWH    911 - 980
YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE    981 - 1050
LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLK   1051 - 1120
DDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKL   1121 - 1190
YETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH   1191 - 1260
KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ   1261 - 1330
LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF   1331 - 1400
MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPP   1401 - 1470
FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQ   1471 - 1540
TSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDA   1541 - 1610
KSHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQL   1611 - 1680
TLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITL   1681 - 1750
KCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQT   1751 - 1820
GGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL   1821 - 1890
NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPS   1891 - 1960
TVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQRLLLYDGDLDEAVGMLLEGCHAEF   1961 - 2030
DGNTAIKECLDVLSSSGVFLNNASGREKDECTATPSSFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTV   2031 - 2100
INSEFSQSGKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDSENILTNYENQSRVETNERA   2101 - 2170
NECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHSQGSF   2171 - 2240
NDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKSLNMISSNPQVQY   2241 - 2310
HNDKYISNTSGEDEKTHPGFQQMPEDKEDESEIEEYSCAVTPGGDTDNAIVSLTCATPLLDETISASDYE   2311 - 2380
TSLLNDQQNNTGTDTDSDDDFYDTPLFEDDDHDSLLLDGDDRDCLHPEDYDTLQEENDETASPADVFYDV   2381 - 2450
SKENENSMVPQGAPVGSLSVKNKAHCLQDFLMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTN   2451 - 2520
ILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSEESYGDYIYDS   2521 - 2590
NDQDDDDDDGIDEEGGGIRDENGKPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEK   2591 - 2660
QQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHEMVLKDVLPPIIKDTESEKTFGPASISH   2661 - 2730
DNNNISSTSELGTDLANTKVKLIQGSELPELTDSVKGKDEYFKNMTPKVDSSLDHIICTEPDLIGKPAEE   2731 - 2800
SHLSLIASVTDKDPQGNGSDLIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNT   2801 - 2870
RDSFKLINSQFPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISD   2871 - 2940
DITSDITSWEGNTHFEESFTDGPEKELDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITAPPMKEHLQLG   2941 - 3010
VNNTKEKSTSTQKDSPLNDMIQSNDLCSKESISGGGTEISQFTPESIEATLSILSRKHVEDVGKNDFLQS   3011 - 3080
ERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQALSPRSQEKEVQIPELSQVFVEDVKDILKS   3081 - 3150
RLKEGHMNPQEVEEPSACADTKILIQNLIKRITTSQLVNEASTVPSDSQMSDSSGVSPMTNSSELKPESR   3151 - 3220
DDPFCIGNLKSELLLNILKQDQHSQKITGVFELMRELTHMEYDLEKRGITSKVLPLQLENIFYKLLADGY   3221 - 3290
SEKIEHVGDFNQKACSTSEMMEEKPHILGDIKSKEGNYYSPNLETVKEIGLESSTVWASTLPRDEKLKDL   3291 - 3360
CNDFPSHLECTSGSKEMASGDSSTEQFSSELQQCLQHTEKMHEYLTLLQDMKPPLDNQESLDNNLEALKN   3361 - 3430
QLRQLETFELGLAPIAVILRKDMKLAEEFLKSLPSDFPRGHVEELSISHQSLKTAFSSLSNVSSERTKQI   3431 - 3500
MLAIDSEMSKLAVSHEEFLHKLKSFSDWVSEKSKSVKDIEIVNVQDSEYVKKRLEFLKNVLKDLGHTKMQ   3501 - 3570
LETTAFDVQFFISEYAQDLSPNQSKQLLRLLNTTQKCFLDVQESVTTQVERLETQLHLEQDLDDQKIVAE   3571 - 3640
RQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF   3641 - 3710
LKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE   3711 - 3780
NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY   3781 - 3850
QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHS   3851 - 3920
LQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV   3921 - 3990
LEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL   3991 - 4060
QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT   4061 - 4130
LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN   4131 - 4200
IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL   4201 - 4270
FENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA   4271 - 4340
LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS   4341 - 4410
LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGL   4411 - 4480
TSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA   4481 - 4550
VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL   4551 - 4620
EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ   4621 - 4690
GILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS   4691 - 4760
SSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDV   4761 - 4830
EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS   4831 - 4900
HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW   4901 - 4970
IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI   4971 - 5040
QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS   5041 - 5110
LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTI   5111 - 5180
REMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG   5181 - 5250
IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQ   5251 - 5320
LNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA   5321 - 5390
LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA   5391 - 5460
TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI   5461 - 5530
GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHS   5531 - 5600
RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQA   5601 - 5670
LLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV   5671 - 5740
ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYR   5741 - 5810
LVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR   5811 - 5880
HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW   5881 - 5950
PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYV   5951 - 6020
AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN   6021 - 6090
VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELA   6091 - 6160
EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG   6161 - 6230
EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL   6231 - 6300
ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQH   6301 - 6370
KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA   6371 - 6440
GNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL   6441 - 6510
ASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE   6511 - 6580
TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHRE   6581 - 6650
QIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWL   6651 - 6720
EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE   6721 - 6790
LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAF   6791 - 6860
QKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV   6861 - 6930
VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITT   6931 - 7000
IKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK   7001 - 7070
ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIET   7071 - 7140
KNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRID   7141 - 7210
KDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIED   7211 - 7280
EVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPC   7281 - 7350
RVHHHGSKMLRSESNSSITTTQPTIAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRS   7351 - 7420
TSVSSQAAQAASPQVPATTTPKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS   7421 - 7490
RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSP   7491 - 7560
ASKLDKSSKR                                                               7561 - 7570
//

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Disease (7)

Expression

Differential Expression (30)

Synonym

Gene

PANTHER Protein Class (3)

Ortholog (1)

UniProt Keyword (33)

GO Function (6)

GO Component (23)

GO Process (10)

Compartment GO Term (91)

IMPC Phenotype (3)

OMIM Phenotype (2)

MGI Phenotype (17)

GWAS Trait (5)

HCA RNA Cell Line (56)

Pathway (8)

PDB (1)

Gene RIF (27)

AA Sequence

Text Mined References (85)

Tbio Dystonin

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