PAX2
Paired box protein Pax-2
Protein Summary
Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
- ENST00000355243
- ENSP00000347385
- ENSG00000075891
- ENST00000370296
- ENSP00000359319
- ENST00000428433
- ENSP00000396259
- FSGS7
- PAPRS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.91 | ||
biological term | 0.83 | ||
phenotype | 0.77 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1106.43 (req: < 5)
Gene RIFs: 134 (req: <= 3)
Antibodies: 424 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1106.43 (req: >= 5)
Gene RIFs: 134 (req: > 3)
Antibodies: 424 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 71
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0