CREB5
Cyclic AMP-responsive element-binding protein 5
Protein Summary
Binds to the cAMP response element and activates transcription. The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000357727
- ENSP00000350359
- ENSG00000146592
- ENST00000396298
- ENSP00000379592
- ENST00000396299
- ENSP00000379593
- ENST00000396300
- ENSP00000379594
- ENST00000409603
- ENSP00000387197
- CREBPA
- CREB-5
- CREBPA
- CRE-BPA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.93 | ||
virus perturbation | 0.9 | ||
kinase perturbation | 0.84 | ||
transcription factor | 0.81 | ||
microRNA | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.89 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 193 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.89 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 193 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0