| Tbio | Ras association domain-containing protein 7 |
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.0e-08 |
| Astrocytoma, Pilocytic | 3081 | 1.3e-05 |
| group 4 medulloblastoma | 1855 | 4.3e-04 |
| breast carcinoma | 1638 | 2.4e-03 |
| Disease | log2 FC | p |
|---|---|---|
| Astrocytoma, Pilocytic | -1.100 | 1.3e-05 |
| breast carcinoma | 1.300 | 2.4e-03 |
| group 4 medulloblastoma | -1.100 | 4.3e-04 |
| ovarian cancer | -1.400 | 2.0e-08 |
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQ 1 - 70 ATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPG 71 - 140 PAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQAL 141 - 210 DAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQEL 211 - 280 EELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDA 281 - 350 ELLEVAAAPAPEWCPLAAQPQAL 351 - 373 //
