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Tbio
RASSF7
Ras association domain-containing protein 7

Protein Summary
Description
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397582
  • ENSP00000380712
  • ENSG00000099849
  • ENST00000397583
  • ENSP00000380713
  • ENST00000431809
  • ENSP00000403068
  • ENST00000454668
  • ENSP00000405606
  • ENST00000622905
  • ENSP00000479652
  • ENSG00000273859

Symbol
  • C11orf13
  • HRC1
  • HRC1
  • HRAS1
  • C11orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.75
transcription factor
0.62
disease perturbation
0.56
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.38   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.38   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0