Tbio PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Protein Summary

Description

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• Q02809
• B4DR87
• Q96AV9
• Q9H132

Gene Name

• PLOD1

Ensembl ID

• ENST00000196061
• ENSP00000196061
• ENSG00000083444

Symbol

• LLH
• PLOD
• LH
• LH1
• LLH
• EDS6
• PLOD
• EDSKCL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
protein complex	0.88
molecular function	0.86
PubMedID	0.78
histone modification site profile	0.75

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.18   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 124   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.18   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0