Tchem FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4

Protein Summary

Description

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q02790
• D3DUQ1
• Q9UCP1
• Q9UCV7
• PPIase FKBP4

Gene Name

• FKBP4

Ensembl ID

• ENST00000001008
• ENSP00000001008
• ENSG00000004478

Symbol

• FKBP52
• HBI
• p52
• Hsp56
• FKBP51
• FKBP52
• FKBP59
• PPIase

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
molecular function	1
kinase perturbation	0.99
interacting protein	0.9
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Isomerase / Peptidyl-prolyl Cis-trans Isomerase Fkbp4

Protein / Chaperone / Peptidyl-prolyl Cis-trans Isomerase Fkbp4

Protein / Calcium-binding Protein / Peptidyl-prolyl Cis-trans Isomerase Fkbp4

DTO Classes

Protein / Enzyme / Isomerase / Peptidyl-prolyl Cis-trans Isomerase Fkbp4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 583.08   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 600   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 583.08   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1