| Tbio | Transcription factor Sp4 |
Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]
The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]
Comments
| Disease | Target Count |
|---|---|
| Bipolar Disorder | 266 |
| Major Depressive Disorder | 106 |
| Schizophrenia | 503 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3099 | 8.76537950433423E-13 |
| ovarian cancer | 8492 | 1.9426920891315E-5 |
| primary Sjogren syndrome | 789 | 3.11777230491704E-4 |
| group 3 medulloblastoma | 2254 | 0.0125027693882024 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.200 | 0.013 |
| primary Sjogren syndrome | 1.200 | 0.000 |
| Breast cancer | -1.200 | 0.000 |
| ovarian cancer | -1.800 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG |
| Opossum | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26431879 | O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities. |
| 26049820 | Results indicate that SP4 S770 phosphorylation is increased in the cerebellum in bipolar disorder that committed suicide and in severe schizophrenia, and may be part of a degradation signal that controls Sp4 abundance in cerebellar granule neurons |
| 25915526 | Results found that SP4 S770 phosphorylation was significantly increased in lymphocytes in first-episode psychosis compared to controls. |
| 25175639 | The results of this study suggest that SP4 and SP1 upregulation may be part of the mechanisms deregulated downstream of glutamate signalling pathways in schizophrenia |
| 23941741 | This study shows reduced SP4 protein levels in first-episode psychosis in lymphocytes, suggesting that these transcription factors are potential peripheral biomarkers of psychotic spectrum disorders in the early stages. |
| 23540600 | This study showed that SP1, SP3 and SP4 protein levels inversely correlated with negative symptoms in the cerebellum. |
| 22614877 | Significantly increased SP4 relative expression levels are observed in patients with Alzheimer's disease, compared with controls. |
| 22017217 | This study demonistrated that The transcription factor SP4 is reduced in postmortem cerebellum of bipolar disorder subjects. |
| 21919647 | Ascorbic acid decreased RKO and SW480 colon cancer cell proliferation and induced apoptosis and necrosis, accompanied by downregulation of Sp1, Sp3, and Sp4 proteins. |
| 20634195 | Sp4 hypomorphic mice could therefore serve as a genetic model to investigate impaired NMDA functions resulting from loss-of-function mutations of human SP4 gene in schizophrenia and/or other psychiatric disorders. |
| More... |
MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQ 1 - 70 QIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKT 71 - 140 KSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTA 141 - 210 ANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGT 211 - 280 GQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYAST 281 - 350 SASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAI 351 - 420 PPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGL 421 - 490 SQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAG 491 - 560 QQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNC 561 - 630 REGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRT 631 - 700 HTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDS 701 - 770 NPATPNVSTNMEEF 771 - 784 //
| PMID | Year | Title |
|---|---|---|
| 26431879 | 2015 | O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities. |
| 26049820 | 2015 | Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects. |
| 25915526 | 2015 | Phosphorylation of transcription factor specificity protein 4 is increased in peripheral blood mononuclear cells of first-episode psychosis. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25175639 | 2014 | Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia. |
| 23941741 | 2013 | Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis. |
| 23540600 | 2013 | Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 23103227 | 2012 | Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese. |
| 22614877 | 2012 | Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration. |
| More... |
