| Tbio | Transcription factor Sp4 |
Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]
The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bipolar Disorder | 666 | 3.826 | 1.9 |
| Schizophrenia | 1160 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 8.8e-13 |
| ovarian cancer | 8520 | 1.9e-05 |
| primary Sjogren syndrome | 735 | 3.1e-04 |
| group 3 medulloblastoma | 4104 | 1.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Mental Depression | 333 | 0.0 | 0.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hereditary spastic paraplegia 4 | 7 | 3.153 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -1.200 | 8.8e-13 |
| group 3 medulloblastoma | 1.200 | 1.3e-02 |
| ovarian cancer | -1.800 | 1.9e-05 |
| primary Sjogren syndrome | 1.200 | 3.1e-04 |
MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQ 1 - 70 QIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKT 71 - 140 KSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTA 141 - 210 ANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVAAGGGT 211 - 280 GQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYAST 281 - 350 SASSSERTIEESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAI 351 - 420 PPQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGL 421 - 490 SQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAG 491 - 560 QQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPGKRLRRVACSCPNC 561 - 630 REGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRT 631 - 700 HTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDS 701 - 770 NPATPNVSTNMEEF 771 - 784 //
