Property Summary

NCBI Gene PubMed Count 15
PubMed Score 38.00
PubTator Score 48.41

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count
Liver Cirrhosis, Experimental 108
Disease Target Count P-value
lung carcinoma 2844 4.41391013841698E-30
non-small cell lung cancer 2798 1.07376010081051E-13
psoriasis 6685 1.79018378059999E-12
atypical teratoid / rhabdoid tumor 4369 6.8506094600925E-10
malignant mesothelioma 3163 5.25709539558959E-8
group 4 medulloblastoma 1875 1.49267348601657E-7
ovarian cancer 8492 1.86256413297205E-7
ependymoma 2514 2.77484086819665E-7
ulcerative colitis 2087 9.8646733561123E-7
pediatric high grade glioma 2712 2.13802599214557E-6
osteosarcoma 7933 5.22230648652846E-6
glioblastoma 5572 1.64520754420538E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 1.99154774090521E-5
Pick disease 1893 1.11549252374534E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 1.94273615916102E-4
interstitial cystitis 2299 2.68026613664985E-4
medulloblastoma, large-cell 6234 4.696664986173E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00324699781523587
primitive neuroectodermal tumor 3031 0.00373292744049436
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00984323755142569
subependymal giant cell astrocytoma 2287 0.0142237383813907
esophageal adenocarcinoma 737 0.0480394874508609
Disease Target Count Z-score Confidence
Chromosome 3q29 microduplication syndrome 6 3.404 1.7
Disease Target Count
Chromosome 3Q29 Deletion Syndrome 1

Expression

Synonym

Accession Q02338 D3DXC0 Q96ET1 Q9BRZ4
Symbols BDH
SDR9C1

Gene

PANTHER Protein Class (2)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA EggNOG

Gene RIF (2)

PMID Text
21791085 Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines.
20877624 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFGFS      1 - 70
LAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWG     71 - 140
LVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCI    141 - 210
TKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEK    211 - 280
IAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR           281 - 343
//

Text Mined References (17)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
21791085 2011 Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
19027726 2009 The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11752456 2001 Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.
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