Tbio NRG1 Pro-neuregulin-1, membrane-bound isoform

Protein Summary

Description

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q02297
• A5YAK4
• A5YAK5
• A8K1L2
• B7Z4Z3
• E9PHH4
• O14667
• P98202
• Q02298
• Q02299
• Q07110
• Q07111
• Q12779
• Q12780
• Q12781
• Q12782
• Q12783
• Q12784
• Q15491
• Q7RTV9
• Q7RTW0
• Q7RTW1
• Q7RTW2
• Q8NFN1
• Q8NFN2
• Q8NFN3
• Q9UPE3
• Pro-NRG1

Gene Name

• NRG1

Ensembl ID

• ENST00000287842
• ENSP00000287842
• ENSG00000157168
• ENST00000356819
• ENSP00000349275
• ENST00000405005
• ENSP00000384620
• ENST00000519301
• ENSP00000429582
• ENST00000520407
• ENSP00000434640
• ENST00000520502
• ENSP00000433289
• ENST00000521670
• ENSP00000428828
• ENST00000523079
• ENSP00000430120

Symbol

• GGF
• HGL
• HRGA
• NDF
• SMDF
• GGF
• HGL
• HRG
• NDF
• ARIA
• GGF2
• HRG1
• HRGA
• SMDF
• MST131
• MSTP131
• NRG1-IT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
trait	1
biological process	0.99
protein domain	0.97
disease	0.87

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Pro-neuregulin-1, Membrane-bound Isoform

DTO Classes

Protein / Signaling / Growth Factor / Pro-neuregulin-1, Membrane-bound Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1537.18   (req: < 5)

Gene RIFs: 439   (req: <= 3)

Antibodies: 854   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1537.18   (req: >= 5)

Gene RIFs: 439   (req: > 3)

Antibodies: 854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0