Tclin GUCY1B1 Guanylate cyclase soluble subunit beta-1

Protein Summary

Description

Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q02153
• B7Z426
• Q86WY5
• GCS-beta-1

Gene Name

• GUCY1B1

Ensembl ID

• ENST00000264424
• ENSP00000264424
• ENSG00000061918
• ENST00000503520
• ENSP00000420842
• ENST00000505764
• ENSP00000426319

Symbol

• GUC1B3
• GUCSB3
• GUCY1B3
• GUCB3
• GC-SB3
• GUC1B3
• GUCSB3
• GUCY1B3
• GC-S-beta-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.67   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.67   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7