Property Summary

NCBI Gene PubMed Count 59
PubMed Score 22.91
PubTator Score 98.47

Knowledge Summary

Patent (22,774)

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 1.01416185098133E-31
posterior fossa group A ependymoma 1511 8.90307276599974E-17
non-small cell lung cancer 2798 5.35834348913906E-15
chronic lymphosyte leukemia 232 1.35529809980777E-9
lung adenocarcinoma 2714 6.7288893552943E-9
ovarian cancer 8492 7.80382211027526E-8
cystic fibrosis 1670 1.41869876301158E-6
non-inflammatory breast cancer 208 8.78482011076324E-5
sonic hedgehog group medulloblastoma 1482 1.33367049415342E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.92352905232318E-4
osteosarcoma 7933 6.03992775866372E-4
medulloblastoma, large-cell 6234 0.00174863327936555
atypical teratoid / rhabdoid tumor 4369 0.00967595613708959
glioblastoma 5572 0.0119376901230004
pituitary cancer 1972 0.0121816486675963
active ulcerative colitis 477 0.0388068007723377
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Hemolytic anemia 70 0.0 1.0

Expression

Synonym

Accession Q01973 Q5VVX6 Q66K77 Q92776
Symbols NTRKR1
dJ537F10.1

Gene

  Ortholog (11)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid
C. elegans OMA Inparanoid

 GWAS Trait (1)

Gene RIF (50)

PMID Text
27126945 expression of ROR1 was significantly higher in colorectal carcinoma tissues than in tumor-adjacent tissues
26862065 the b-catenin-independent WNT score correlated with reduced overall survival only in the metastasized situation . This is in line with the in vitro results of the alternative WNT receptors ROR1 and ROR2, which foster invasion
26725982 This study reports an unanticipated function of ROR1 as a scaffold of cavin-1 and caveolin-1, two essential structural components of caveolae.
26690702 This study identifies an interaction between ROR1 and ROR2 that is required for Wnt5a signaling that promotes leukemia chemotaxis and proliferation.
26661061 The present findings thus support our notion that ROR1 sustains lung adenocarcinoma survival, at least in part, through direct physical interaction with ASK1
26576539 miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer
26575700 these findings revealed that miR382 inhibits migration and invision by targeting ROR1 through regulating EMT in ovarian cancer, and might serve as a tumor suppressor in ovarian cancer.
26562161 Data show that the majority of chronic lymphocytic leukemia (CLL) patients had antibodies against receptor tyrosine kinase ROR1.
26515598 Data show that silencing receptor tyrosine kinases (RTKs) ROR2 and ROR1 has a strong inhibitory effect on the ability of ovarian cancer cells to proliferate, migrate and invade.
26245996 High expression of ROR1 (63%), pAkt (36%), and pCREB (20%) was observed in gastric adenocarcinomas, and expression of these proteins was well intercorrelated.
More...

AA Sequence

MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTS      1 - 70
LGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVV     71 - 140
SSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIG    141 - 210
TSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLP    211 - 280
NCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTAL    281 - 350
RFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL    351 - 420
LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKG    421 - 490
HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDL    491 - 560
HEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVK    561 - 630
ISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQE    631 - 700
VIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQT    701 - 770
TSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG    771 - 840
PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPY    841 - 910
KIDSKQASLLGDANIHGHTESMISAEL                                               911 - 937
//

Text Mined References (62)

PMID Year Title
27126945 2016 [Down-regulation of receptor-tyrosine-kinase-like orphan receptor 1 suppresses cell growth and enhances apoptosis in human colorectal carcinoma].
26862065 2016 ?-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases.
26725982 2016 ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
26690702 2016 Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation.
26661061 2016 Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma.
26576539 2015 miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer.
26575700 2016 miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer.
26562161 2015 Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia.
26515598 2015 Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion.
26245996 2015 Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma.
More...