Property Summary

NCBI Gene PubMed Count 50
Grant Count 74
R01 Count 60
Funding $12,163,288
PubMed Score 116.27
PubTator Score 242.06

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (19)

Disease log2 FC p
astrocytic glioma -2.700 0.002
ependymoma -3.600 0.000
oligodendroglioma -2.200 0.010
glioblastoma -4.800 0.000
osteosarcoma 1.279 0.001
medulloblastoma -4.900 0.000
atypical teratoid / rhabdoid tumor -5.000 0.000
medulloblastoma, large-cell -4.900 0.000
primitive neuroectodermal tumor -4.500 0.000
autosomal dominant Emery-Dreifuss muscul... -1.335 0.001
acute quadriplegic myopathy -1.422 0.000
adult high grade glioma -4.200 0.000
pilocytic astrocytoma -4.000 0.000
aldosterone-producing adenoma 1.170 0.034
subependymal giant cell astrocytoma -4.035 0.042
Pick disease -1.300 0.036
ovarian cancer 1.100 0.000
pituitary cancer 2.000 0.000
psoriasis -1.700 0.000

Synonym

Accession Q01814 O00766 Q12994 Q16818 PMCA2
Symbols PMCA2
PMCA2a
PMCA2i

Gene

PANTHER Protein Class (2)

Gene RIF (23)

PMID Text
26729871 PMCA2 interacts with HER2 in specific actin-rich membrane domains.
25690014 PMCA2b resulted in rapid and highly PMCA abundance-sensitive clearance of store-operated Ca2+ entry-mediated Ca2+ transients.
25661196 SERCA and PMCA pump activities are strongly affected by the localization of F508del-CFTR protein.
23620727 ATP2B2 might play a role in the etiology of autism in Chinese Han population.
22349217 G293S and V586M mutations in the PMCA2 Calcium Transporting ATPase of the stereocilia are associated with deafness. (Review)
22047666 The human mutant of PMCA2 exacerbated the deafness produced by a cadherin 23 mutation. The human mutant failed to impair the Ca(2+) ejection by the pump.
21757185 These results provide converging evidence for an association between ATP2B2 gene variants and autism in male subjects
21672522 these data suggest that full polarization is a prerequisite for proper positioning of the PMCA2w variants in the apical membrane domain of polarized cells.
20971118 It appears that Ca extrusion via the sarcolemmal Ca ATPase occurs only at the t-tubules, and is not regulated by basal PKA activity.
20663896 Apical scaffolding protein NHERF2 modulates the localization of alternatively spliced plasma membrane Ca2+ pump 2B variants in polarized epithelial cells.
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AA Sequence

MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPG      1 - 70
TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGG     71 - 140
AEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVV    141 - 210
GDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNS    211 - 280
QTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQ    281 - 350
QDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT    351 - 420
FVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM    421 - 490
GNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGA    491 - 560
LPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEI    561 - 630
VLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCI    631 - 700
CVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEK    701 - 770
GEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIA    771 - 840
GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQM    841 - 910
LWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQID    911 - 980
SGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFG    981 - 1050
GKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAE   1051 - 1120
RELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDL   1121 - 1190
EEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL                    1191 - 1243
//

Text Mined References (53)

PMID Year Title
26729871 2016 PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
25690014 2015 Plasma membrane Ca²?-ATPases can shape the pattern of Ca²? transients induced by store-operated Ca²? entry.
25661196 2015 SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.
24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23620727 2013 The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.
22349217 2012 Hair cells, plasma membrane Ca²? ATPase and deafness.
22047666 2011 Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect.
21757185 2011 Converging evidence for an association of ATP2B2 allelic variants with autism in male subjects.
21672522 2011 Apical localization of PMCA2w/b is enhanced in terminally polarized MDCK cells.
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