Tchem SLC7A5 Large neutral amino acids transporter small subunit 1

Protein Summary

Description

Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

Uniprot Accession IDs

• Q01650
• Q8IV97
• Q9UBN8
• Q9UP15
• Q9UQC0

Gene Name

• SLC7A5

Ensembl ID

• ENST00000261622
• ENSP00000261622
• ENSG00000103257

Symbol

• CD98LC
• LAT1
• MPE16
• E16
• CD98
• LAT1
• 4F2LC
• MPE16
• D16S469E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
kinase perturbation	0.96
transcription factor binding site profile	0.9
interacting protein	0.86
PubMedID	0.79

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc3 And Slc7 Families Of Heteromeric Amino Acid Transporters (Hats) / Slc7 Family / Large Neutral Amino Acids Transporter Small Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.57   (req: < 5)

Gene RIFs: 172   (req: <= 3)

Antibodies: 351   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.57   (req: >= 5)

Gene RIFs: 172   (req: > 3)

Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0