Property Summary

NCBI Gene PubMed Count 23
PubMed Score 158.12
PubTator Score 25.98

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 1.4631182962802E-23
juvenile dermatomyositis 1189 1.08037180810241E-16
ulcerative colitis 2087 2.31315743782288E-8
ovarian cancer 8492 4.27327818144721E-8
posterior fossa group A ependymoma 1511 1.71134528499431E-7
pituitary cancer 1972 2.81714283725819E-7
tuberculosis 1563 1.56468894442982E-5
lung cancer 4473 5.30907542398161E-5
systemic lupus erythematosus 172 7.87205323174307E-5
acute quadriplegic myopathy 1157 8.15849303845157E-5
interstitial cystitis 2299 1.27571001610915E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 1.29156925213002E-4
primary pancreatic ductal adenocarcinoma 1271 6.14066512226977E-4
dermatomyositis 967 7.55332042548274E-4
pancreatic cancer 2300 0.00207208997407732
group 4 medulloblastoma 1875 0.00391145436572882
glioblastoma 5572 0.0079244058120544
medulloblastoma, large-cell 6234 0.011047819644922
Multiple myeloma 1328 0.0163168059008357
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0252874689760124
esophageal adenocarcinoma 737 0.0260208674824537
active Crohn's disease 918 0.0287428289289038
Down syndrome 548 0.0444124815723589



Accession Q01629 Q6FH82 Q96DA8
Symbols 1-8D


  Ortholog (3)

Species Source
Chimp OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid

Gene RIF (22)

26387945 IFITM2 and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection.
26387945 HIV-1 gp120 interacts with IFITM2
26387945 HIV-1 infectivity is inhibited when IFITM2 is expressed by the virus producing cell (293T cells)
26354436 propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific
26116899 HIV-1 gp120 interacts with IFITM2
25552713 Host IFITM3,IFITM2 and IFITM1 facilitate morphogenesis of the human cytomegalovirus assembly.
25464829 Incorporation of IFITM1, IFITM2 and IFITM3 into HIV-1 virions impair viral fusion and spread.
25464829 HIV-1 gp120 interacts with IFITM2
25464829 HIV-1 infectivity is inhibited when IFITM2 is expressed by the virus producing cell (293T cells)
25463599 HIV-1 gp120 interacts with IFITM2

AA Sequence


Text Mined References (28)

PMID Year Title
26387945 2015 IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
26354436 2015 The Interferon-induced Transmembrane Proteins, IFITM1, IFITM2, and IFITM3 Inhibit Hepatitis C Virus Entry.
25552713 2015 Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.
25464829 2014 IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
25422070 2014 IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
24992036 2014 G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.
23720721 2013 IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus.
23376165 2013 Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins.
23358889 2013 IFITM proteins restrict viral membrane hemifusion.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.