Property Summary

NCBI Gene PubMed Count 37
PubMed Score 7.62
PubTator Score 117.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Osteoporosis 259
Disease Target Count P-value
juvenile dermatomyositis 1189 3.18856077364882E-13
Duchenne muscular dystrophy 602 8.48539609227205E-9
ovarian cancer 8492 1.3041359602714E-5
acute quadriplegic myopathy 1157 1.72304639670067E-4
dermatomyositis 967 0.00126355129894597
Becker muscular dystrophy 187 0.00220956842234569
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00488984051074677
pancreatic cancer 2300 0.00496660917567229
primary pancreatic ductal adenocarcinoma 1271 0.00505585828801534
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0052399128136859
Waldenstrons macroglobulinemia 765 0.00647476294206747
glioblastoma 5572 0.0073533057632537
intraductal papillary-mucinous adenoma (IPMA) 2956 0.021566309917277
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0267941886271922
Breast cancer 3099 0.034017826985178

Expression

Synonym

Accession Q01518 Q53HR7 Q5T0S1 Q5T0S2 Q6I9U6 CAP 1
Symbols CAP
CAP1-PEN

Gene

PDB

1K8F  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
S.cerevisiae OMA Inparanoid

Gene RIF (17)

PMID Text
25652936 a high expression of CAP1 is involved in the pathogenesis of EOC, and that the downregulation of CAP1 in tumor cells may be a therapeutic target for the treatment of patients with EOC.
25371324 CAP1 is involved in the brain metastasis in non-small cell lung cancer.CAP1 overexpression is associated with poor prognosis in non-small cell lung cancer patients.
25332229 This study demonstrated an inverse relationship between CAP1 and MMP-9 expression, high expression of MMP-9 and low expression of CAP1 in those with chronic obstructive pulmonary disease compared with the non-chronic obstructive pulmonary disease group.
24606903 Overexpression of CAP1 in monocytes enhanced the resistin-induced increased activity of the cAMP-dependent signaling.
24522810 Overexpression of CAP1 is associated with breast carcinoma.
24509166 CAP1 might be a potential molecular targeted therapy for surgery and immune treatment.
24359721 results indicate that upregulated expression of CAP1 might contribute heavily to the metastasis of hepatocellular carcinoma.
23904342 Findings suggest that CAP1 (cyclase-associated protein 1) is involved in the metastasis of esophageal squamous cell carcinoma, and increased expression may indicate a poor prognosis.
23842884 overexpression of CAP1 in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer.
23737525 CAP1 depletion also led to changes in cofilin phosphorylation and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading.
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AA Sequence

MADMQNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAAPYVQAFDSLLAGPVAEYLKISKEIGGDVQ      1 - 70
KHAEMVHTGLKLERALLVTASQCQQPAENKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQA     71 - 140
LGWVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSKT    141 - 210
GPVAKELSGLPSGPSAGSCPPPPPPCPPPPPVSTISCSYESASRSSLFAQINQGESITHALKHVSDDMKT    211 - 280
HKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKRATKKEPAVLELEGKKWRVENQENVSNLVIEDTELKQV    281 - 350
AYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDVKVQVMGKVPTISINKTDGCHAYL    351 - 420
SKNSLDCEIVSAKSSEMNVLIPTEGGDFNEFPVPEQFKTLWNGQKLVTTVTEIAG                   421 - 475
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Text Mined References (54)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25652936 2015 CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation.
25371324 2015 Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer.
25332229 2014 Relationship between expression of matrix metalloproteinase-9 and adenylyl cyclase-associated protein 1 in chronic obstructive pulmonary disease.
25114211 2014 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
24606903 2014 Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes.
24522810 2014 High expression and prognostic role of CAP1 and CtBP2 in breast carcinoma: associated with E-cadherin and cell proliferation.
24509166 2014 Knocking down the expression of adenylate cyclase-associated protein 1 inhibits the proliferation and migration of breast cancer cells.
24359721 2014 Upregulated expression of CAP1 is associated with tumor migration and metastasis in hepatocellular carcinoma.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
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