Tclin PDE1B Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Protein Summary

Description

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q01064
• Q92825
• Q96KP3
• Cam-PDE 1B

Gene Name

• PDE1B

Ensembl ID

• ENST00000243052
• ENSP00000243052
• ENSG00000123360
• ENST00000550620
• ENSP00000448519

Symbol

• PDE1B1
• PDES1B
• PDE1B1
• PDES1B
• HEL-S-79p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.91
protein domain	0.73
gene perturbation	0.69
ligand (protein)	0.68
histone modification site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.8   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 345   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.8   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 345   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1