Property Summary

NCBI Gene PubMed Count 1,207
PubMed Score 2174.65
PubTator Score 2386.90

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
juvenile dermatomyositis 1189 1.70848656941452E-10
glioblastoma multiforme 347 5.57018474250475E-10
acute quadriplegic myopathy 1157 2.31886927968541E-8
atypical teratoid/rhabdoid tumor 1095 1.68944278167404E-7
lung cancer 4473 4.50593404740848E-7
Amyotrophic Lateral Sclerosis 432 2.09023505388327E-6
psoriasis 6685 4.85487974038236E-5
autosomal dominant Emery-Dreifuss muscular dystrophy 499 6.71016700819883E-5
hepatocellular carcinoma 550 6.72271483268293E-5
colon cancer 1475 2.68179639421881E-4
gastric cancer 436 2.93925380594068E-4
primitive neuroectodermal tumor 3031 5.96351494808704E-4
malignant mesothelioma 3163 0.0015000509763816
osteosarcoma 7933 0.00526614593130493
pancreatic carcinoma 567 0.00729209537586852
pancreatic cancer 2300 0.00729209537586854
ovarian cancer 8492 0.00815693971788324
active Crohn's disease 918 0.00883883522888457
subependymal giant cell astrocytoma 2287 0.0101313654698411
Disease Target Count Z-score Confidence
Cancer 2346 6.729 3.4
Disease Target Count Z-score Confidence
Lipoma 19 5.414 2.7




1YCR   4HFZ   2F1Y   2FOP   3MQS   2VJE   2VJF   1RV1   1T4E   1T4F   1Z1M   2AXI   2C6A   2C6B   2GV2   2HDP   2LZG   2M86   2MPS   2RUH   3EQS   3G03   3IUX   3IWY   3JZK   3JZR   3JZS   3LBK   3LBL   3LNJ   3LNZ   3TJ2   3TPX   3TU1   3V3B   3VBG   3VZV   3W69   4DIJ   4ERE   4ERF   4HBM   4HG7   4JV7   4JV9   4JVE   4JVR   4JWR   4MDN   4MDQ   4OAS   4OBA   4OCC   4ODE   4ODF   4OGN   4OGT   4OGV   4OQ3   4QO4   4QOC   4UD7   4UE1   4UMN   4WT2   4XXB   4ZYC   4ZYF   4ZYI   5AFG   5C5A   5HMH   5HMI   5HMK   5LN2  

  Ortholog (10)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

MLP Assay (9)

AID Type Active / Inconclusive / Inactive Description
1230 screening 220 / 0 / 207678 E3 Ligase HTS_1536
1394 confirmatory 41 / 0 / 159 E3 Ligase dose-response_384
1442 confirmatory 32 / 0 / 8 E3 Ligase_Mutant_Dose Response
1444 confirmatory 40 / 0 / 0 E3 Ligase_WT_Dose Response
485346 screening 10029 / 0 / 321731 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format.
488776 summary 0 / 0 / 0 Summary of small molecule Inhibitors of Mdm2/MdmX interaction
489028 screening 5580 / 0 / 4478 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format.
504593 confirmatory 19 / 0 / 1 Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format
504601 screening 739 / 0 / 3 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2

Gene RIF (1169)

27273943 Overexpression of MDM2 independently predicted a reduced risk of death in non-small cell lung carcinoma patients.
27187988 The proposed non-linear feedback control and perturbations compensation method for the p53-mdm2 system can result in more efficient chemotherapy schemes where the infusion of medication will be better administered.
27015167 We conducted updated meta-analyses to evaluate the role of MDM2 T309G polymorphism in urinary tract cancer susceptibility.
26997440 Report a new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification.
26992741 we demonstrated that rLZ-8 promoted the interaction between MDM2 and Slug, resulting in Slug degradation
26992014 results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein
26977010 MDM2 and PSMA may co-regulate the expression of certain MMPs and, thus, the functionality of cells in metastatic breast cancer.
26945408 Meta-analysis results suggest that homozygote GG alleles of MDM2 SNP309 may be a low-penetrant risk factor for head and neck cancer, and G allele may confer nasopharyngeal cancer susceptibility.
26926424 RNF12 is a novel positive regulator of p53 pathway and an external E3 ubiquitin ligase for MDM2 destruction.
26840476 G/G genotype was not associated with tumor recurrence after surgical treatment and it did not show any correlation with other prognostic factors.

AA Sequence


Text Mined References (1217)

PMID Year Title
27273943 Prognostic significance of overexpressed matrix metalloproteinase-2, mouse-double minute: 2 homolog and epidermal growth factor receptor in non-small cell lung cancer.
27187988 2016 Non-linear feedback control of the p53 protein-mdm2 inhibitor system using the derivative-free non-linear Kalman filter.
27015167 2016 Murine Double Minute 2 SNP T309G Polymorphism and Urinary Tract Cancer Risk: A Meta-Analysis.
26997440 2016 A new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification.
26992741 2016 Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation.
26992014 2016 Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction.
26977010 2016 MDM2 and PSMA Play Inhibitory Roles in Metastatic Breast Cancer Cells Through Regulation of Matrix Metalloproteinases.
26945408 2016 Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.
26926424 2016 RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction.
26840476 2015 ASSOCIATION BETWEEN MURINE DOUBLE MINUTE 2 - T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment.