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Tbio
MYBPC1
Myosin-binding protein C, slow-type

Protein Summary
Description
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361466
  • ENSP00000354849
  • ENSG00000196091
  • ENST00000361685
  • ENSP00000354845
  • ENST00000392934
  • ENSP00000376665
  • ENST00000452455
  • ENSP00000400908
  • ENST00000536007
  • ENSP00000446128
  • ENST00000541119
  • ENSP00000442847
  • ENST00000545503
  • ENSP00000440034
  • ENST00000547405
  • ENSP00000448175
  • ENST00000550270
  • ENSP00000449702
  • ENST00000553190
  • ENSP00000447900

Symbol
  • MYBPCS
  • LCCS4
  • MYBPCC
  • MYBPCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.65
cell line
0.61
tissue
0.53
transcription factor
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.47   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.47   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0