Tbio PPP2R2B Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

Protein Summary

Description

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q00005
• A6NEJ2
• A8K102
• B3KPD0
• B7Z2F2
• B7Z304
• D3DQF7
• D3DQF8
• G3V149

Gene Name

• PPP2R2B

Ensembl ID

• ENST00000336640
• ENSP00000336591
• ENSG00000156475
• ENST00000394409
• ENSP00000377931
• ENST00000394411
• ENSP00000377933
• ENST00000394413
• ENSP00000377935
• ENST00000394414
• ENSP00000377936
• ENST00000453001
• ENSP00000398779
• ENST00000504198
• ENSP00000421396
• ENST00000508545
• ENSP00000431320

Symbol

• PR52B
• SCA12
• B55BETA
• PR55BETA
• PP2ABBETA
• PP2APR55B
• PR2ABBETA
• PR55-BETA
• PP2AB55BETA
• PR2AB55BETA
• PP2APR55BETA
• PR2APR55BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
protein domain	0.85
interacting protein	0.84
disease perturbation	0.83
tissue sample	0.79

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta Isoform

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.25   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.25   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0