PXYLP1
2-phosphoxylose phosphatase 1
Protein Summary
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.
- ENST00000286353
- ENSP00000286353
- ENSG00000155893
- ENST00000393010
- ENSP00000376733
- ACPL2
- HEL124
- XYLP
- XYLP
- ACPL2
- HEL124
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.86 | ||
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.83 | ||
transcription factor binding site profile | 0.82 | ||
small molecule perturbation | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.96 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 131 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 245.96 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 131 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0