| Tbio | Receptor-type tyrosine-protein phosphatase zeta |
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Helicobacter Infections | 5 | 0.0 | 0.0 |
| Pneumoconiosis | 15 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Schizophrenia | 1160 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 1.5e-20 |
| breast carcinoma | 1638 | 7.6e-16 |
| ovarian cancer | 8520 | 2.2e-12 |
| non-small cell lung cancer | 2890 | 9.9e-12 |
| Astrocytoma, Pilocytic | 3081 | 2.1e-08 |
| colon cancer | 1478 | 5.9e-07 |
| glioblastoma | 5792 | 3.2e-05 |
| adult high grade glioma | 3801 | 3.6e-04 |
| cystic fibrosis | 1696 | 7.2e-04 |
| interstitial cystitis | 2312 | 1.3e-03 |
| medulloblastoma, large-cell | 6241 | 1.7e-03 |
| oligodendroglioma | 2850 | 2.1e-03 |
| pituitary cancer | 1972 | 3.1e-03 |
| astrocytic glioma | 2597 | 6.5e-03 |
| medulloblastoma | 720 | 1.3e-02 |
| esophageal adenocarcinoma | 737 | 2.4e-02 |
| nasopharyngeal carcinoma | 1058 | 2.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hyperlysinemia | 6 | 3.736 | 1.9 |
| Hyperkalemic periodic paralysis | 9 | 3.507 | 1.8 |
| Disease | Target Count |
|---|---|
| Helicobacter pylori infection, susceptibility to | 2 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.600 | 3.6e-04 |
| astrocytic glioma | 2.200 | 6.5e-03 |
| Astrocytoma, Pilocytic | 1.900 | 2.1e-08 |
| Breast cancer | -4.100 | 1.5e-20 |
| breast carcinoma | -1.400 | 7.6e-16 |
| colon cancer | -2.000 | 5.9e-07 |
| cystic fibrosis | 2.300 | 7.2e-04 |
| esophageal adenocarcinoma | -1.200 | 2.4e-02 |
| glioblastoma | 1.500 | 3.2e-05 |
| interstitial cystitis | 1.800 | 1.3e-03 |
| medulloblastoma | -1.700 | 1.3e-02 |
| medulloblastoma, large-cell | -3.100 | 1.7e-03 |
| nasopharyngeal carcinoma | -2.000 | 2.7e-02 |
| non-small cell lung cancer | 3.415 | 9.9e-12 |
| oligodendroglioma | 2.500 | 2.1e-03 |
| ovarian cancer | -4.300 | 2.2e-12 |
| pituitary cancer | -1.700 | 3.1e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDL 1 - 70 TQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGS 71 - 140 EHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQA 141 - 210 ALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDY 211 - 280 LQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLY 281 - 350 QQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE 351 - 420 LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFS 421 - 490 GKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESL 491 - 560 NTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNA 561 - 630 SEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMS 631 - 700 QGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPL 701 - 770 VTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ 771 - 840 ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEP 841 - 910 PSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPT 911 - 980 ASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGN 981 - 1050 ETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPE 1051 - 1120 NNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASD 1121 - 1190 VDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL 1191 - 1260 TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKL 1261 - 1330 IHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVSPHRDGSVTSTKLLFPSKATS 1331 - 1400 ELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQN 1401 - 1470 NPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAW 1471 - 1540 AVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFH 1541 - 1610 VSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR 1611 - 1680 VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDN 1681 - 1750 KHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1751 - 1820 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRV 1821 - 1890 VTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVN 1891 - 1960 IFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLL 1961 - 2030 SQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLL 2031 - 2100 HTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDF 2101 - 2170 ILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLM 2171 - 2240 HQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNIAES 2241 - 2310 LESLV 2311 - 2315 //
