Tchem PTPN13 Tyrosine-protein phosphatase non-receptor type 13

Protein Summary

Description

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q12923
• B2RTR0
• Q15159
• Q15263
• Q15264
• Q15265
• Q15674
• Q16826
• Q8IWH7
• Q9NYN9
• Q9UDA8

Gene Name

• PTPN13

Ensembl ID

• ENST00000316707
• ENSP00000322675
• ENSG00000163629
• ENST00000411767
• ENSP00000407249
• ENST00000427191
• ENSP00000408368
• ENST00000436978
• ENSP00000394794
• ENST00000511467
• ENSP00000426626

Symbol

• PNP1
• PTP1E
• PTPL1
• PNP1
• FAP-1
• PTP1E
• PTPL1
• PTPLE
• PTP-BL
• hPTP1E
• PTP-BAS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.89
kinase perturbation	0.88
gene perturbation	0.85
hub protein	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.75   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 194   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.75   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0