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  5. Prostaglandin E2 receptor EP4 subtype

Tclin Prostaglandin E2 receptor EP4 subtype

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 278
NCBI Gene PubMed Count 157
PubMed Score 970.67
PubTator Score 393.04

Knowledge Summary

Patent (38,513)

TINX Plot

  Disease (7)

Disease Target Count
Physiological Sexual Disorders 4
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6

Expression

  Differential Expression (32)

Disease log2 FC p
acute myeloid leukemia 1.500 2.2e-02
adrenocortical adenoma -1.535 5.2e-03
adrenocortical carcinoma -2.727 3.8e-06
aldosterone-producing adenoma -1.778 9.4e-03
Astrocytoma, Pilocytic 1.700 6.5e-04
autosomal dominant Emery-Dreifuss muscul... 1.491 9.5e-04
Bipolar Disorder 1.509 4.6e-02
Breast cancer -1.400 1.3e-04
breast carcinoma -1.200 9.6e-18
colon cancer -2.100 2.3e-02
cystic fibrosis 1.500 5.9e-03
dermatomyositis 1.500 2.6e-03
Duchenne muscular dystrophy 1.147 6.3e-06
esophageal adenocarcinoma 1.900 2.0e-02
Gaucher disease type 3 -1.400 2.5e-02
glioblastoma 1.700 1.2e-02
group 3 medulloblastoma 1.400 4.0e-02
intraductal papillary-mucinous adenoma (... -2.000 6.6e-04
intraductal papillary-mucinous carcinoma... -1.500 2.7e-03
intraductal papillary-mucinous neoplasm ... -2.400 1.7e-03
invasive ductal carcinoma -1.182 1.8e-02
juvenile dermatomyositis 1.314 4.1e-07
lung adenocarcinoma -1.700 6.1e-04
lung cancer -2.500 7.2e-04
lung carcinoma -2.600 6.2e-38
non-small cell lung cancer -1.415 3.5e-15
osteosarcoma 1.474 1.2e-04
ovarian cancer -3.900 3.1e-08
pancreatic cancer -1.100 1.2e-04
posterior fossa group A ependymoma 1.500 9.5e-04
primary pancreatic ductal adenocarcinoma -2.264 8.7e-04
primary Sjogren syndrome 1.800 3.9e-04

Synonym

Accession P35408 Q3MJ87 PGE receptor EP4 subtype
Symbols EP4
EP4R

Gene

PTGER4

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

 UniProt Keyword (12)

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 GO Function (1)

 GO Component (3)

 GO Process (19)

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 Compartment GO Term (29)

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 MGI Phenotype (14)

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 GWAS Trait (1)

 HCA RNA Cell Line (54)

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Pathway (17)

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Drug (1)

Structure of dinoprostone

dinoprostone
pKi 9.77

Ligand (276)

Structure of CHEMBL3260761

CHEMBL3260761
pKi 7.00

Structure of CHEMBL3793912

CHEMBL3793912
pIC50 7.02

Structure of CHEMBL3260437

CHEMBL3260437
pKi 7.05

Structure of CHEMBL3792999

CHEMBL3792999
pIC50 7.06

Structure of CHEMBL3260760

CHEMBL3260760
pKi 7.07

Structure of CHEMBL3793994

CHEMBL3793994
pIC50 7.08

Structure of CHEMBL1669024

CHEMBL1669024
pIC50 7.10

Structure of CHEMBL192303

CHEMBL192303
pKi 7.10

Structure of CHEMBL3260430

CHEMBL3260430
pKi 7.10

Structure of CHEMBL3260431

CHEMBL3260431
pKi 7.10

Structure of CHEMBL1669008

CHEMBL1669008
pIC50 7.11

Structure of CHEMBL3600788

CHEMBL3600788
pIC50 7.11

Structure of CHEMBL1645146

CHEMBL1645146
pKi 7.12

Structure of CHEMBL3686863

CHEMBL3686863
pKi 7.12

Structure of CHEMBL1644012

CHEMBL1644012
pKi 7.13

Structure of CHEMBL3753221

CHEMBL3753221
pEC50 7.14

Structure of CHEMBL3753133

CHEMBL3753133
pIC50 7.14

Structure of CHEMBL3600884

CHEMBL3600884
pIC50 7.14

Structure of CHEMBL3115074

CHEMBL3115074
pIC50 7.16

Structure of CHEMBL1644015

CHEMBL1644015
pKi 7.17

Gene RIF (126)

AA Sequence 

MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTL      1 - 70
LVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTL     71 - 140
FAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGAL    141 - 210
LRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLV    211 - 280
VLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCR    281 - 350
IGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG    351 - 420
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI      421 - 488
//

Text Mined References (157)

PMID Year Title