Tclin | Prostaglandin E2 receptor EP4 subtype |
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 323 |
NCBI Gene PubMed Count | 157 |
PubMed Score | 970.67 |
PubTator Score | 393.04 |
Disease | Target Count |
---|---|
Physiological Sexual Disorders | 4 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Inflammatory bowel disease | 151 | 3.257 | 1.6 |
Ankylosing spondylitis | 140 | 0.0 | 2.2 |
Brain cancer | 30 | 0.0 | 1.0 |
Crohn's disease | 321 | 0.0 | 1.7 |
Malignant glioma | 26 | 0.0 | 1.0 |
Multiple Sclerosis | 540 | 0.0 | 2.5 |
ulcerative colitis | 1819 | 0.0 | 3.0 |
Accession | P35408 Q3MJ87 PGE receptor EP4 subtype |
Symbols |
EP4 EP4R |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL3260761
pKi 7.00
CHEMBL3793912
pIC50 7.02
CHEMBL3260437
pKi 7.05
CHEMBL3792999
pIC50 7.06
CHEMBL3260760
pKi 7.07
CHEMBL3793994
pIC50 7.08
CHEMBL1669024
pIC50 7.10
CHEMBL192303
pKi 7.10
CHEMBL3260430
pKi 7.10
CHEMBL3260431
pKi 7.10
CHEMBL1669008
pIC50 7.11
CHEMBL3600788
pIC50 7.11
CHEMBL1645146
pKi 7.12
CHEMBL3686863
pKi 7.12
CHEMBL1644012
pKi 7.13
CHEMBL3753221
pEC50 7.14
CHEMBL3753133
pIC50 7.14
CHEMBL3600884
pIC50 7.14
CHEMBL3115074
pIC50 7.16
CHEMBL1644015
pKi 7.17
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTL 1 - 70 LVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTL 71 - 140 FAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGAL 141 - 210 LRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLV 211 - 280 VLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCR 281 - 350 IGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG 351 - 420 MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI 421 - 488 //