Tbio PTCHD4 Patched domain-containing protein 4

Protein Summary

Description

Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.

Uniprot Accession IDs

• Q6ZW05
• A0A0A7EN49
• B0QZ29
• B2RPC0
• B4DRK3
• B4DTR9
• Q5T884

Gene Name

• PTCHD4

Ensembl ID

• ENST00000339488
• ENSP00000341914
• ENSG00000244694

Symbol

• C6orf138
• PTCH53
• PTCH53
• C6orf138
• dJ402H5.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.75
cell type or tissue	0.72
tissue sample	0.66
histone modification site profile	0.61
microRNA	0.61

Protein Classes

PANTHER Classes

Protein / Receptor / Patched Domain-containing Protein 4

DTO Classes

Protein / Receptor / Patched Domain-containing Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0