Tbio PSRC1 Proline/serine-rich coiled-coil protein 1

Protein Summary

Description

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q6PGN9
• Q5T2Z3
• Q6ZTI8
• Q71MG3
• Q9BV77

Gene Name

• PSRC1

Ensembl ID

• ENST00000369903
• ENSP00000358919
• ENSG00000134222
• ENST00000369904
• ENSP00000358920
• ENST00000369907
• ENSP00000358923
• ENST00000369909
• ENSP00000358925
• ENST00000409138
• ENSP00000474667
• ENST00000409267
• ENSP00000386323

Symbol

• DDA3
• DDA3
• FP3214

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
biological process	0.79
virus perturbation	0.76
trait	0.75
drug perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.2   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.2   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0