Tdark PRSS58 Serine protease 58

Protein Summary

Description

This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IYP2
• B3KVJ6
• D3DXD2

Gene Name

• PRSS58

Ensembl ID

• ENST00000547058
• ENSP00000447588
• ENSG00000258223
• ENST00000552471
• ENSP00000446916
• ENST00000621886
• ENSP00000478535
• ENSG00000276785
• ENST00000622880
• ENSP00000479165

Symbol

• TRY1
• TRYX3
• TRY1
• PRSS1
• TRYX3
• UNQ2540

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
gene perturbation	0.47
tissue	0.47
cell line	0.42
tissue sample	0.36

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Serine Protease 58

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Serine Protease 58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.98   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 32   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.98   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0