You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRRT2
Proline-rich transmembrane protein 2

Protein Summary
Description
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300797
  • ENSP00000300797
  • ENSG00000167371
  • ENST00000358758
  • ENSP00000351608
  • ENST00000567659
  • ENSP00000456226
  • ENST00000572820
  • ENSP00000458291
  • ENST00000636131
  • ENSP00000490390
  • ENST00000637064
  • ENSP00000490826
  • ENST00000645336
  • ENSP00000496452
  • ENST00000647876
  • ENSP00000498021

Symbol
  • PKC
  • EKD1
  • ICCA
  • BFIC2
  • BFIS2
  • DSPB3
  • DYT10
  • FICCA
  • IFITMD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.62
biological term
0.61
tissue
0.57
transcription factor binding site profile
0.54
microRNA
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.7   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.7   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0