PRRG1
Transmembrane gamma-carboxyglutamic acid protein 1
Protein Summary
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
- ENST00000378628
- ENSP00000367894
- ENSG00000130962
- ENST00000449135
- ENSP00000390332
- ENST00000463135
- ENSP00000419999
- ENST00000542554
- ENSP00000444278
- ENST00000543642
- ENSP00000443271
- PRGP1
- TMG1
- PRGP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.75 | ||
virus perturbation | 0.68 | ||
histone modification site profile | 0.67 | ||
transcription factor perturbation | 0.61 | ||
tissue | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.16 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.16 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0