Tbio PRR7 Proline-rich protein 7

Protein Summary

Description

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222).

Uniprot Accession IDs

• Q8TB68
• Q8WU53
• Q9BTA7

Gene Name

• PRR7

Ensembl ID

• ENST00000323249
• ENSP00000327168
• ENSG00000131188
• ENST00000502922
• ENSP00000420872
• ENST00000510492
• ENSP00000421039

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.87
transcription factor binding site profile	0.76
small molecule perturbation	0.73
histone modification site profile	0.66
tissue sample	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0