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Tbio
PRPSAP2
Phosphoribosyl pyrophosphate synthase-associated protein 2

Protein Summary
Description
Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis. This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268835
  • ENSP00000268835
  • ENSG00000141127
  • ENST00000419071
  • ENSP00000392536
  • ENST00000536323
  • ENSP00000443967
  • ENST00000542013
  • ENSP00000439129
  • ENST00000610773
  • ENSP00000481322

Symbol
  • PAP41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.71
transcription factor
0.69
histone modification site profile
0.62
phenotype
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0