Property Summary

NCBI Gene PubMed Count 20
PubMed Score 48.83
PubTator Score 16.44

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (16)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.310 4.9e-03
Multiple myeloma 1.387 7.4e-05
astrocytic glioma -2.800 3.6e-03
oligodendroglioma -2.800 1.3e-02
osteosarcoma -1.352 1.8e-02
ependymoma -1.100 5.4e-03
atypical teratoid / rhabdoid tumor -1.100 2.8e-04
glioblastoma -1.200 1.2e-03
medulloblastoma -1.700 4.8e-03
medulloblastoma, large-cell -1.600 5.0e-03
primitive neuroectodermal tumor -1.300 2.2e-02
adrenocortical adenoma -2.699 3.4e-03
adrenocortical carcinoma -2.347 3.8e-03
tuberculosis 1.300 8.1e-07
Polycystic Ovary Syndrome 1.251 2.1e-02
ovarian cancer -1.100 1.7e-02

Protein-protein Interaction (6)

Gene RIF (5)

PMID Text
26004865 PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway.
25816608 The expression of different genes encoding subunits of PRPS enzyme is affected by hypoxia in tumor glioma cells, but the effect of hypoxia is modified by suppression of endoplasmic reticulum stress signaling enzyme ERN1.
25149475 Meta-analysis of genome-wide association studies identifies a novel variant in PRPS2 on Xp22.3 as susceptibility locus for systemic lupus erythematosus.
18677108 Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets.
18409517 increased activity of this gene leads to gout

AA Sequence

MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMEL      1 - 70
LIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI     71 - 140
PVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGD    141 - 210
VKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDK    211 - 280
MKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL                                    281 - 318
//

Text Mined References (21)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26004865 2015 PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells.
25816608 Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.
25416956 2014 A proteome-scale map of the human interactome network.
25149475 2015 Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
21269460 2011 Initial characterization of the human central proteome.
18677108 2008 Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.
18409517 2008 [Increased activity of PRPP synthetase].
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
7572345 1995 Mammalian phosphoribosyl-pyrophosphate synthetase.
2560337 1989 Deduced amino acid sequence from human phosphoribosylpyrophosphate synthetase subunit II cDNA.
2538352 1989 Molecular cloning and sequencing of human cDNA for phosphoribosyl pyrophosphate synthetase subunit II.
2537655 1989 Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript.
2536962 1989 Localization of human phosphoribosylpyrophosphate synthetase subunit I and II genes (PRPS1 and PRPS2) to different regions of the X chromosome and assignment of two PRPS1-related genes to autosomes.
1962753 1990 Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.
1602151 1992 Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.
1314091 1992 Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.