PRPF8
Pre-mRNA-processing-splicing factor 8
Protein Summary
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]
- ENST00000304992
- ENSP00000304350
- ENSG00000174231
- ENST00000572621
- ENSP00000460348
- ENST00000614672
- ENSP00000479194
- ENSG00000274442
- ENST00000634039
- ENSP00000488611
- PRPC8
- PRP8
- RP13
- HPRP8
- PRPC8
- SNRNP220
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
protein domain | 1 | ||
disease perturbation | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.48 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.48 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0