Tchem PRKACB cAMP-dependent protein kinase catalytic subunit beta

Protein Summary

Description

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P22694
• B1APG4
• B4DKB0
• B4E2Q1
• Q14VH1
• Q59GC0
• Q5BNE9
• Q5BNF0
• Q5BNF1
• Q5BNF2
• Q5BNF3
• Q5CZ92
• Q5T1K3
• Q7Z3M1
• Q8IYR5
• Q8IZQ0
• Q96B09
• PKA C-beta

Gene Name

• PRKACB

Ensembl ID

• ENST00000370682
• ENSP00000359716
• ENSG00000142875
• ENST00000370685
• ENSP00000359719
• ENST00000370688
• ENSP00000359722
• ENST00000370689
• ENSP00000359723
• ENST00000394839
• ENSP00000378315
• ENST00000446538
• ENSP00000401252
• ENST00000610703
• ENSP00000481980
• ENST00000614872
• ENSP00000479722

Symbol

• PKACB
• PKA C-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
hub protein	0.99
molecular function	0.98
pathway	0.93
histone modification site profile	0.91

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Pka Family / Camp-dependent Protein Kinase Catalytic Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.78   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 374   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.78   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0