| Tbio | DNA primase large subunit |
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 6.4e-16 |
| atypical teratoid / rhabdoid tumor | 5112 | 8.7e-07 |
| glioblastoma | 5792 | 9.7e-07 |
| primitive neuroectodermal tumor | 3035 | 4.1e-06 |
| medulloblastoma, large-cell | 6241 | 8.3e-06 |
| lung adenocarcinoma | 2716 | 3.6e-05 |
| posterior fossa group A ependymoma | 468 | 9.3e-05 |
| adult high grade glioma | 3801 | 1.4e-04 |
| group 3 medulloblastoma | 4104 | 2.5e-04 |
| psoriasis | 6694 | 9.6e-04 |
| lung cancer | 4740 | 1.0e-02 |
| osteosarcoma | 7950 | 1.3e-02 |
| Gaucher disease type 1 | 180 | 3.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.200 | 1.4e-04 |
| atypical teratoid / rhabdoid tumor | 1.400 | 8.7e-07 |
| Gaucher disease type 1 | -1.100 | 3.9e-02 |
| glioblastoma | 1.300 | 9.7e-07 |
| group 3 medulloblastoma | 1.600 | 2.5e-04 |
| lung adenocarcinoma | 1.300 | 3.6e-05 |
| lung cancer | 1.400 | 1.0e-02 |
| medulloblastoma, large-cell | 2.000 | 8.3e-06 |
| non-small cell lung cancer | 1.273 | 6.4e-16 |
| osteosarcoma | 2.630 | 1.3e-02 |
| posterior fossa group A ependymoma | 1.100 | 9.3e-05 |
| primitive neuroectodermal tumor | 1.400 | 4.1e-06 |
| psoriasis | -1.400 | 9.6e-04 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQY 1 - 70 QSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKI 71 - 140 QDFLKDSQLQFEAISDEEKTLREQEIVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVP 141 - 210 LKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQGNVGKISLDQIDLLS 211 - 280 TKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIR 281 - 350 HSFGKEGKRTDYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHY 351 - 420 QVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILNGGKDIKKEPIQPETPQPKPSVQKTKDASSALASL 421 - 490 NSSLEMDMEGLEDYFSEDS 491 - 509 //
